Influence of a Non-ionic Surfactant on the Release of Rhodamine B from Poly(vinyl) Alcohol/Polyoxalate/Span-80 Composite Nanofibers Prepared by Emulsion Electrospinning

Controlling drug release using a nanocomposite method is crucial; however, burst must be avoided in order to obtain effective controllable release. In this study, poly(vinyl) alcohol/polyoxalate/Span-80 (PVA/ POX/ Span-80) composite nanofibers loaded with Rhodamine B were produced emulsion electrospinning. The objective of work was evaluate the cooperative roles POX and Span-80 on nanofibrous scaffold stability regulation by monitoring performance from electrospun nanofibers. microstructure hydrophilic properties studied scanning electron microscopy (SEM), water contact angle, swelling tests. According results, increasing content had significant effect size angles increased as increased. governed two-stage diffusion mechanism that greatly influenced PVA/POX ratios Span-80. To compare behavior, non-emulsion without prepared control samples. Emulsion found at slower rate than vitro profiles revealed released fibers sustainable manner no initial observed. These findings imply can potentially used deliver drugs, nutraceuticals, fragrances prolonged